Proton pump inhibitors and preeclampsia risk among 157 720 women: A swedish population register-based cohort study

R Hastie; L Bergman; CA Cluver; A Wikman; NJ Hannan; SP Walker; AK Wikström; S Tong; S Hesselman

Journal article

Proton pump inhibitors and preeclampsia risk among 157 720 women: A swedish population register-based cohort study

R Hastie, L Bergman, CA Cluver, A Wikman, NJ Hannan, SP Walker, AK Wikström, S Tong, S Hesselman

Hypertension | LIPPINCOTT WILLIAMS & WILKINS | Published : 2019

DOI: 10.1161/HYPERTENSIONAHA.118.12547

Abstract

Preeclampsia is a hypertensive disorder of pregnancy with a high rate of maternal and neonatal morbidity and mortality. The only definite treatment is delivery. Preclinical investigations have identified proton pump inhibitors (PPIs), which are commonly used to treat reflux during pregnancy, as a potential treatment for preeclampsia. The aim of this study was to determine the association between PPI use during pregnancy and preeclampsia risk in a population-based register cohort. Using the Swedish Pregnancy Register, we conducted a cohort study of nulliparous pregnant women delivering from January 2013 to July 2017. Associations between PPI use and preeclampsia were investigated using logist..

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University of Melbourne Researchers

Roxanne Hastie Author

Natalie Hannan Author

Susan Walker Author

Stephen Tong Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

R. Hastie was supported by a Melbourne Medical School, Department of Obstetrics and Gynaecology Fellowship; S. Tong (No. 1136418), F. Brownfoot (No. 1142636), and N.J. Hannan (No. 1146128) were supported by National Health and Medical Research Council Fellowships. L. Bergman and S. Hesselman were supported via a postdoc position at Center for clinical research, Falun, Sweden. The funders had no role in study design, data collection, analysis, decision to publish or the preparation of the manuscript.